Freddy J.K. Toloza, Diabetes, Lipids and Metabolism Laboratory, School of Medicine, Universidad de los Andes, Colombia
Carlos O. Mendivil, Diabetes, Lipids and Metabolism Laboratory, School of Medicine, Universidad de los Andes; Section of Endocrinology, Fundación Santa Fe de Bogotá. Bogotá, Colombia
Aldosterone is a key regulator of water and electrolyte metabolism, but recent evidence from multiple lines of research also identifies it as a major player in other chronic disorders, particularly diabetes and the metabolic syndrome. In this review, we summarize rel- evant aspects of aldosterone production, secretion, action, the way aldosterone and the mineralocorticoid receptor may impact energy metabolism, and useful take-home messages concerning mineralocorticoid antagonism in patients with type 2 diabetes mellitus.
Keywords: Aldosterone. Electrolyte metabolism. Diabetes. Metabolic syndrome.
